M.S. Kharasch, Merthiolate, and Autism

One of my most prized books is a tattered copy of Grignard Reactions of Nonmetallic Substances, by M.S. Kharasch and Otto Reinmuth, published in 1954 by Prentice-Hall.  It is a 1384 page tome containing a vast number of examples of Grignard reagent chemistry and reaction chemistry with extensive references through 1954.

Morris Selig Kharasch was a professor at the University of Chicago and is primarily known for his work with free radical chemistry.  To Kharasch is credited much of the early work in sorting out the mechanism of anti-Markovnikov addition of HBr to olefins. Reinmuth was the second Editor of the Journal of Chemical Education (1933-40).  Two coworkers, Frank Mayo and Cheves Walling, went on to make contributions toward the development of vinyl polymerization.

Later in his career Kharasch turned to the examination of the Grignard reagent and many of its reactions.  Among the list of his students and post-docs are H.C. Brown and George Buchi.  Kharasch was instrumental in the founding of the Journal of Organic Chemistry and served on the Editorial Board for many years.

It is interesting to note that Kharasch is credited with the patenting of Thimerosal in 1927, a product also known under the trade name Merthiolate which has been used as an antimicrobial additive in vaccines.

2 thoughts on “M.S. Kharasch, Merthiolate, and Autism

  1. bill

    I have Colin Eaborn’s book on silicon chemistry as well as Sommer’s. Both make for great reading. What is especially interesting about Sommer’s book is that it is about stereochemistry in silicon reactions and was published just before the Cahn-Ingold-Prelog R/S rules. Yes, a book on stereochemistry – that mentions absolute configurations – and no R/S assignments. At first I kept thinking, why no R/S and then it dawned on me!

    I think you should send Kharasch’s book to google and have it scanned so the rest of us can savor its knowledge!

    Reply
  2. gaussling Post author

    Good point, I wonder how that works? Where does Google get these books to scan? There are many books that will never be reprinted that should be archived so folks can access them.

    Reply

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