Author Archives: gaussling

About gaussling

Gaussling is a senior scientist in the chemical business. He occasionally breaks glassware, spreads confusion and has been known to generate new forms of hazardous waste. Gaussling also digs aerospace, geology, and community theatre.

American Idiopath

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I recently developed a condition where I have ear pain and partial facial paralysis. Ear aches I can deal with, but when my face quits working, I go to the doc. So, that’s what happened. The ENT said that it resembled Bells palsy and the cause was idiopathic.

I can just imagine an attending physician and a resident in medical school taking future idiopathic specialists on their rounds. The doc walks in and greets a patient with an ear ache and a face that doesn’t work. “Yessir” he says with resignation, “another case of idiopathic syndrome. We just don’t know what the hell happened.” The resident turns to the med students and says gravely, “Look at this patient closely. Try not to confuse the distant stare and slack jaw with idiopathic disease. Even though this patient is from Iowa, we are convinced that there is an idiopathic condition overprinted on his presentation.”

The attending physician stands there thoughtfully for a moment, raises a bristled eyebrow and glances at his watch. “Let’s go people. The idiopathology wing is full of patients with mysterious conditions.” With that they shuffle off down the hall.

Update

A round of acyclovir and prednisone cleared up the apparent Bells palsy. I am symmetric again and can pucker up to whistle a tune.

On the 4-Methylcyclohexanemethanol Spill

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The fouling of public waters in West Virginia by 4-methylcyclohexanemethanol (MCHM) is regrettable and my heart goes out to all of the families whose lives have been and are disrupted by the spill. In my judgment the descriptions of the substance found in Wikipedia and ChemSpider seem very evenhanded given what is known presently about the toxicology of the substance. The SymBioSys LASSO numbers found in ChemSpider are reassuring in the sense that the structure of MCHM does not line up well with the receptors in the list. The low scores are suggestive of substrate mismatch with these receptors based on calculation. That is a good thing. So is the relatively high flash point of 80 °C.

There are several uses of this substance. At the large scale its use has been patented as a frothing agent for coal beneficiation (US 4915825). That patent is now expired. It is useful for separating coal particles from inorganic mineral particles. Other uses include the preparation of ester derivatives to produce plasticizers either as a stand alone ester or, as a listing in SciFinder shows, a hydrophobic co-monomer.

From what I have heard in the media, the secondary containment failed, allowing material to discharge into the nearby river. This is easy to figure out. A visual inspection by plant EH&S should have noticed failure of the secondary containment during periodic inspection and flagged it for repairs. The US Chemical Safety Board is investigating and will eventually publish a finding.

It seems to me that the people of WV must be willing to publically demonstrate en mass if anything is to change there. The lack of regulatory oversight on facilities like this is not surprising. It is exactly as intended by the power brokers of the state.

Lithium Fires

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Ran into an interesting recommendation on fighting a lithium fire in Joshi, D.K., et al, Organic Process Research & Development, 2005, 9, 997-1002.

In addition to the usual admonitions on the handling of a reactive metal like Li, they warned that water, sand, carbon dioxide, dry chemical, or halon should not be used. Rather, they suggest dry graphite or lithium chloride instead.  This seems quite reasonable to me, having reacted both silica and CO2 with magnesium powder in chemical demonstrations in a previous life. If Mg will reduce SiO2 and CO2, then hot/burning lithium ought to be reactive as well.

A similar recommendation is given in Furr, A.K. CRC Handbook of Laboratory Safety, 5th Edition, p. 299, ISBN 0-8493-2523-4.

Comments on the cable TV series “Gold Rush”

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I’m a fan of Gold Rush on the Discovery Channel and have been since the beginning. Aside from the producers constant over-dramatization and spreading the content a little too thin over the time block, I’d have to say that my main criticism would be with the miners themselves.

What I would throw on the table is the observation that there is a troublesome lack of analytical data supporting the miner’s choices of where to dig a cut. The few episodes where core samples have been taken, useful data was obtained and decisions made therefrom. But the holes were paid for grudgingly and the range covered too miserly. A sufficiently capitalized operation would be sure to survey the ore body and make the decision to bring in the heavy equipment on the basis of data.

Obviously they have been chronically short of capital for their operations. Fortunately for them, over the last 2 seasons they have been able to upgrade their wash plants, trommels, and earth moving equipment. Must be the TV connection.

But I suppose it is the very lack of capitalization that forms the dramatic basis of the show. Without scarcity there would be no drama. Without the conflicting personalities and dubious decision making there would be only a documentary on gold mining.

I have to imagine that the recent collapse in gold prices will get folded into the dramatic context in the next season.

I truly wish Parker Schnabel, the Hoffman crew, and the Dakota boys the best of luck in their efforts. What the viewers can’t see are the 10,000 details and problems that remain on the editing room floor.

Chemical Process Development

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Lots of semi-batch process development and safety work going on in my lab. We use our reaction calorimeter for a variety of studies now. Naturally we want to know about energy accumulation with a given feed rate or any unforeseen induction or initiation problems in a reaction. We can also home in on recommendations for safe feed rates of reactants into a reaction mass.

What I am beginning to learn from the RC1 work is that running a reaction at low temperature is frequently done for sketchy reasons. Unless there are selectivity or side product issues, you really have to question why the reaction is specified to be run at low temperature. I think some of it comes from habit gained in grad school.  Low temperature may introduce dangerous situations with abrupt initiation by accumulation of unreacted reagents. Or it may lead to overly long feed time with the associated costs of added plant time and labor.

There are reagent incompatibilities like nBuLi in THF above – 15 C or so. But you’ll find that MeTHF is a bit more tolerant of temperature than is THF.

The precise temperature management capabilities (Tr) of an RC1 including the ability to lock on a temperature or precision ramping gives insight on solubility questions or on freezing points. The instrument also provides heat capacity data for engineering calculations. it is a very useful apparatus.

A Big Bronx Cheer for the 2014 Jeep Cherokee!!

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The makers of Jeep have resurrected the standard Jeep Cherokee in, well, how else can I say it … a very stupid way. They have abandoned the classic boxy utility vehicle lines of the old Cherokee in favor of the now popular fat and squat ellipsoidal lines of contemporary design. In other words, it looks like a jelly bean or rugby ball.  The classic 4.0 Liter Cherokee had power to spare and it had the fantastic visibility of an inverted fish tank. It had troubles too, namely bad electric connectors and perhaps an under-designed cooling system. But at least it had the classic squared-off Jeep lines and lots of traction.

But the greatest sin of all was abandoning the 4.0 L straight-6 engine for the 3.2 L engines. Jeep?? WTF!! What were you thinkin’? I would love to meet the committee of marketing pencil necks and constipated MBA’s responsible for this one. It’s a travesty.

So Long Year 2013. Hello 2014!

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Update:  I sit and write at a desk piled with pdf printouts of patents, journal articles, a Phi-Tec 1 handbook, and a great heap of process safety data and reports. I help coworkers find and study patents for their R&D due diligence. The bigger task is running a thermo lab for determining the thermokinetic safety of bulk chemical processing. These two topics, patents and thermodynamics, would induce instant unconsciousness for most folks. An acute boredom-stroke followed by involuntary somnolence and collapse to the floor. Oddly enough, I rather dig these topics- especially the thermodynamics. A single fellow covering these two widely differing topics is entirely a(n) historical artifact, unlikely ever to be repeated.

Several months following throat cancer treatment, my energy and curiosity are back although I still cannot eat solid food due to impaired salivary glands and taste buds.  The head-and-neck-onco-doc says it’ll take 1.5 to 2 years for the spitter to come back online. It is like serving a sentence in the Nestle warehouse living on Boost. I enjoy food vicariously watching the Food Network. This is what the term “food porn” means- watching others enjoy a sensory and emotional experience with food.

The year 2014 will see me spending more time with the urology oncologist. At the last appointment he promised to help keep me on the top side of the grass as long as possible. I have to hold him to it.

An American Parliamentary Republic? Why not?

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Here is an idea for debate. Why not pitch our flawed constitution overboard? Replace it with one that supports a parliamentary form of government rather than the fractious, unworkable presidential system we have now. Who else in the world uses this system of government? Why is it that most other forms of government in the world are parliamentary in structure?

Make the US government more responsive to the citizenry by rendering the election cycle time dependent on confidence in the leadership.

The US constitution needs a rewrite. Among the distortions in the constitution-

  1. The metaphysical equation of money with speech.
  2. The foggy language of the 2nd amendment that engenders armed fanaticism
  3. The indistinct barrier between the secular and theocratic civic influences. Keep religion and other magical thinking out of governance. Preserve freedom from religion.
  4. The near impossibility of getting a bad president or governor out of office.
  5. Clearer language is needed on what is actually meant by the right to petition congress. Currently this has lead to an intractable cancer of corruption between government and the movers of wealth. (Consider the F-35 strike fighter or the lack of tight control over Wall Street investment banks)
  6. Apparently the rules for the waging of foreign wars are indistinct because current constitution or presidential structure seems to allow the US much flexibility and low accountability with invasions and sending ordinance across borders.

There are more problems with the constitution. Maybe the reader has thoughts on this? The problems of presidential systems have been studied and this Slate article summarizing the issues is worth reading.

The Squamous Chronicles. Just pissin’ and moanin’.

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It’s been 16 days since radiation ended. My throat (oropharanx) seems better though the internal blistering has not totally subsided. Fatigue and boredom grind the soul like a rock in my shoe. I’ve collected new books on poetry and science but to no avail. Concentration remains elusive.

Eating is tedious. The g-tube pump is slow and I am not tolerating the nutrient fluid (i.e., “food”) all that well. Food tastes awful and swallowing is problematic.

My other cancer- prostate- is next on the firing line. I won the cancer lottery with an aggressive form that has spread to a lymph node but not to any bones according to the Tc bone scan.  I am under hormone ablation therapy which slows down the spread for a few years anyway. We may start radiation in January. The docs won’t say anything about life expectancy. The urologist is disinclined to treat it surgically. At the UC hospital, they have a tumor board meeting every Tuesday where they discuss cases. It’s nice to know that multiple folks are looking at it.

The Squamous Chronicles. Pointers for the home stretch.

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A few observations for those facing irradiation of the throat.

  • Don’t wait too long with your decision to get a gastric tube put in.
  • Get started with a high calorie regimen early. By week 3 of 6, swallowing suddenly became very painful.
  • Beware the constipating drugs.  For me it has been the anti-nausea drugs and the narcotic pain killers. It is very easy to get behind the curve on this. Find a parallel bowel control regimen and stick with it.
  • Some meds that promote bowel movement are too strong. For me it is Dulcolax.
  • Mucositis is more than just a nuisance. Viscous mucus it produces will trigger gagging and vomiting. Pumping acidic vomit through a raw throat is exactly as fun as it sounds. Mucinex (aka guaifenesin) goes a long way towards keeping this in check. Out of about 20 nurses and docs I’ve had contact with, only one nurse seemed to know this trick.
  • The so called magic mouthwash, Benedryl/Lidocaine/liquid antacid was too viscous for the mucositis.
  • After 63 Gy of therapeutic  x-rays and what I’ll estimate as ca 450 mGy from 35 CT x-rays, a surgical scar will be very sunburned if it was in the beam. It is important to keep it moisturized and covered.  The pharmacy can compound  an ointment composed of 2 % lidocaine in Aquaphore. This works very well.

It is important to let go of some of the independence and allow people to help you. The people around you want to help but feel unable to do anything substantial. Let them drive you around or bring food even if you can’t eat it. They’ll tell you about others they know who have had cancer and perhaps died of it. Even though it may not really be comforting to you, they are reaching out the best way they know how. You have to allow them this because they are under stress as well.