Sometimes it is best to simply shut up and link to a superior post. This is such a time. In a recent posting, one writer, Harold Ambler, comes out against Al Gore in the global warming debate. While I am skeptical about his assertions on the effect of the solar flux on the earths geomagnetic dynamo, I think Ambler otherwise brings together quite a few good points I have seen elsewhere.
The ticket to my seat on the carbon bandwagon will soon post on Ebay.
The artless fools running our American federal government over the last 8 years have been substantially preoccupied with petropolitics and deconstruction of the goverment handed to them by the previous administration. Leading up to the 8 Bush II years were 6 years of a conservative congress who paid more attention to the lurid and scandalous behaviour of Clinton/Lewinski than to the international scene.
Since the collapse of the Soviet Union in the early 1990’s, the USA has been internally preoccupied with: a pageant of neoconservative social engineering proposals; privatization of nearly everything; political consolidation of dominionist megachurches; impeachment of a president for lying about sex; a buildup of militarism following the 9/11 attack; attacking the wrong country (arguably) in response to 9/11; the re-election of a president who has proven to be considerably less than useless; a global financial trainwreck; and, finally, the handoff of a platter of shit sandwiches to the next administration. What a time it has been.
And since the collapse of the Soviet Union, the USA has squandered its substantial goodwill and failed to summon international leadership by Presidents 42 & 43 in the constructive engagement of new Russia. Magic moments in history have come and gone, unused. In the mean time, Russia has experimented with capitalism in their unique way. But the experiment has not been much of a success. So, Russia did what Russia tends to do- it has advanced strongmen into power. And they are KGB alumni as well. Golly, what a surprise.
It could be that Russia might have been refractory to whatever help we might have offered. But we didn’t really try much beyond helping them decommission nuclear warheads.
So, now we see that Russian sentiment is falling back nostalgically towards Joseph Stalin- Uncle Joe. The government is actually confiscating materials archiving the atrocities of Stalin. The rationale is that Stalin made them a superpower, so his indiscretions and sins can be overlooked. Putin and Medvedev- king and rook- are gradually consolidating power the old fashioned way- they’re taking it under the blustering pretense of security. It’s like a game of chess. You advance enough pawns to get control of the middle of the board. Then you castle your king (Putin) and begin the projection of power across the board.
WAWAwawa ..wawa..wawawa..waawaa..waaawaaa..wa..wa……wa……….wa.
The thermometer read -20 F this morning. It hasn’t been that cold for a few years. As I sat in the Jeep listening to my battery die hard, my mind wandered fondly to the green meadows of P-Chem and the Nernst equation. This equation sets forth the relationship between temperature and cell potential. The University of Arizona has this fantastic Nernst simulator (web version) that lets you dial in temperature and immediately see the effect on the voltage of the electrochemical cell. It is plain to see that as the temperature drops, the EMF drops as well.
Knowing that nature wouldn’t let me summon sufficient wattage from my battery, I went back inside and switched on CNN. After seeing multiple replays of an indignant journalist hurling a pair of shoes at our president, I was treated to an ad by the Central Intelligence Agency- the CIA. Yeah, the CIA is advertising on CNN! Take a minute to get your arms around that.
Strangely, uncharacteristically perhaps, I experienced a synergistic swelling of sympathy after seeing the shots of Bush II being assaulted by Iraqi footwear followed by the patriotic CIA ad. For a moment- just a sparkle in time- a quorum of voices in my head agreed that somebody should kick that journalist’s ass. Bush II may be a buffoon, but he is OUR buffoon and nobody should treat him like that. There- I said it.
A Car Czar? What? Are they kidding? Pfffttt!! Industry people barely know how to run the car business. How is a civil servant or political appointee going to direct a bunch of cocky rust belt stiffs in pinstripe suits to drive us into a clean and happy motorized future? Is this a joke? HEY!! Who’s idea is this?
The big three automotive companies need a blood purge. The executives who lead these venerable organizations onto this jeep trail to perdition need to have their heads skewered on a row of pikes planted outside corporate HQ for all to see. There must be a big show of public firings and some tearful, sobbing contrition by the survivors. People who become automobile executives captains of industry should be terrified every day they show up to work, fearing for their careers. If you get too relaxed, You’re Out! Damn’d skippy.
With the revelation that streams of water ejected from the Saturnian moon Enceladus may arise from subsurface liquid water, the space science crowd is abuzz with excitement about the possibility of life on this frosted novelty moon. It seems to me that if there is aqueous life under the surface of Enceladus, then some of it should have been blown ejected above the surface by these geysers. In fact, a few of the hapless critters may be lying about on the surface this very moment wearing an expression of shock and dismay on their frozen xenomorphic faces. How embarrassing for them.
The three cosmic damp spots- Earth, Europa, and Enceladus. I wonder how long it will take for a lander proposal to get serious evaluation? Life on Enceladus is as likely to resemble a microbial mat as anything. A lander would have to consider microscopic examination of samples.
Wow. Major dose of reality. For Th’ Gaussling, this economy fiasco just went from made-for-TV to in-your-face reality. Big chemical producers are pitching 10 % chunks of resourceful humanity overboard. They are burning down inventory levels, pushing back raw material purchases, and stopping capital projects. The reciprocal of the old saw about “a rising tide lifting all boats” is in effect.
Well, everywhere except government. Government seems to continue to build up debt obligations into the tens of terabucks range. Now is a good time to have defense related products- things that have MIL SPEC on them.
But now is when it really sucks to be in advertising, RV sales, and office supplies. Advertising budgets are among the easiest to cut when the flancing of blubber begins.
This is a great time to hire. Lots of job candidates out there with degrees. I’ve been getting Hail Mary resumes from people wildly disconnected from chemistry.
If you are a well paid 50-something, golly, you might as well put a target on your back. This is one of the ways companies can re-jigger their staff to be rid of those expensive, middle aged folk who burden the health insurance pool with those costly diseases. In a recession, a company can use the situation to reset the payroll and have a chance to restaff with cheaper worker bees when things pick back up. That is, if there is anybody left.
Hello Mr. Bush. We hear that you are considering a run for the US Senate. We do not know each other and it is unlikely that our paths will cross. But if you do indeed win a seat in the Senate, then you will be in my life, though somewhat indirectly. You seem like a nice fellow. Let me offer a few thoughts.
Consider that the entire GOP franchise has been badly damaged by your brother, his handlers, and by groups who have perverted the meaning of conservatism. Your brother and his people have presided over the creation of entirely new species of corruption, incompetence, and forms of malfeasance that will take a decade to untangle.
A large fraction of citizens are angry over Bush II arrogance and its willful disregard of good civics. Americans want to move past the Bush epoch: A Bush III period is not welcome.
That being said, it seems that redemption of the family name may lie squarely on your shoulders. Please consider that the direction of this redemption may not be in Washington. It may be elsewhere and may take the form of more humble activity.
Sincerely yours,
Th’ Gaussling
Being a scientist, I am interested in natural phenomena. And, being a gastronaut, I am naturally keen to explore the distant reaches of the food universe. Generally my voyages into multidimensional food space are uneventful. But now and then I encounter foodstuffs that push back. Food that does pressure-volume (PV) work on the internals.
Some foods are capable of generating many moles of gas phase product that is appreciably insoluble in the digestive fluids. The result is an inflation of the gastric spaces and prompt notice to the brain of distress.
Fortunately the good folks at Beano have a commercially available product that in my hands or … ahem … elsewhere … makes a dramatic difference in the discomfort level associated with certain legumes. The secret of this wonder of science is alpha galactosidase. When taken before the first bite of PV generating foods, it causes a drastic reduction in the inflation of the large intestine. This enzyme aids in the hydrolysis of troublesome saccharides that are otherwise left to travel from the small to the large intestine where the gut flora go to town.
All the legume eater has to do is to chew 2 or 3 Beano tablets right before the first spoonfull of chili or pintos. In my half dozen live fire beano tests and one frightening control experiment, I have to say that I am a believer. I am grateful and my family is even more grateful.
Science for the betterment of mankind. Ya gotta love it.
There are as many ways of starting a chemical business as there are people starting them. Entrepreneurs range in profile from smooth talking slicksters to sober, ROI-calculating engineers. Entrepreneurs can also be rather unruly folk. It is not automatically true that business founders are inherently talented at designing and running orgainzations. In fact, they are frequently poor at it. But, successful founders are usually highly focused and are able to attract resources.
A common motivation for starting a business is that the founder is possessed with existential certainty that he/she can operate a business venture better than, say, a former boss or rival. A business founder may be a free spirit, refractory to sensible advice, or may be a solemn Harvard MBA operating by the book. It is not uncommon for a founder to have had several previous failed ventures prior to a successful one.
And make no mistake, the sense of power that a founder feels in the execution of a business plan can be as addictive as heroin or crack. Once a person has had the experience of successfully gathering resources and then allocating them to leverage progress to a goal, they are forever changed. Whether or not they continue the role of managing funds or personnel, their eyes have been opened to the real meaning of power.
Power is the ability to allocate resources.
No matter what kind of chemical business one wishes to start, it is crucial to understand that it will require the accumulation of some kind of resource that you can apply to a problem. That resource can range from your technical reputation, 30 days net of commercial credit, VC monies, or a chemical processing plant. It is all a form of leverage toward the greater goal converting streams of goods and services into streams of cash.
Try to get cash flowing from sales as early as possible. Choosing a Market-Pull activity is the best way to do this.
A chemist starting up a business is able to choose several kinds of general business activities. If you want to be a consultant, you must determine the boundaries of your knowledge and then find demand for that expertise. If you are truly an expert in a field, then more likely than not you know who might buy your services.
If you choose a Technology-Push approach, try to target customers who are willing to be early adopters.
A chemist may be well situated to start an operation offering analytical services. In that case, the enterprising analyst needs to know about underserved demand out in the marketplace. You need to offer a service that prompts people to send a purchase order to you.
If your startup is a one-act pony, it is critical that the pony actually be able to jump through the flaming hoop as advertised. Try to avoid one-act pony business plans. Find Market-Pull products to pay the bills while your Technology-Push products are under development.
A chemist is in a great position to get into formulations. While this might not be strictly a “chemistry’ activity, the walking-around-knowledge of chemicals that a chemist might have probably well exceeds the basic chemistry knowledge of many “experts” in the formulations business. However, a chemists general knowledge may not be applicable for direct application to formulations. A formulator must accumulate specialized knowledge and analytical methods for the materials they handle, including things like rheology, cloud and pour points, fungal contamination, and miscibilities. The level of infrastructure for doing formulations can be dramatically less stringent than chemicals manufacturing as well, requiring less startup capital. That said, formulations may be in demand at the large scale. Puttering around at only the less-than-drum scale may have no future. Again, to be a formulator you need to know what is in demand.
Remember-Sometimes it is dumb to be too smart about things. Be customer oriented. Be honest about strengths and weaknesses. Learn the difference between smart and cagey. Dick was a cagey businessman. Don’t be a Dick.
Fine chemicals manufacture has many success stories. Alfred Bader started his Aldrich empire making what we now call Diazald. Bader was extremely customer service oriented and I believe this was the key to his success. He visited laboratories and asked workers what they needed. If the request was reasonable, he would put the material in the catalog collection. If the chemist-entrepreneur desires to start a catalog fine chemical company to sell reagent chemicals and widgets, then I would advise making a study of that business arena.
An understanding of the regulatory compliance world is critical as well, especially relating to the Toxic Substances Control Act, TSCA. A company may have to start out as being a provider of ‘R&D Only’ products. To freely sell commercial quantities of specialty and fine chemicals, a substance must be on the EPA’s public or confidential lists. If not, then permission must be granted by EPA. This will require a special filing which discloses its manufacturing and/or use process, Personal Protection Equipment (PPE), fugitive dust and corresponding controls on exposures to workers and the environment, vapor releases and method of control, a disclosure of how much of the New Chemical Substance (NCS) gets into the environment, any and all available toxicity data, a Safety Data Sheet, physicochemical data, waste NCS disposal, batch size and yearly production. For less than or equal to 10,000 kg per year a Low Volume Exemption (LVE) can be filed. This is an abbreviated version of a Pre-Manufacturing Notification (PMN) filing which will be examined in greater detail and will take much longer for EPA to complete. EPA has the right to require the submitter to collect certain kinds of toxicological data at the submitters expense. These tests are standardized and are performed by certified labs.
Most advisors to entrepreneurs will say that the prospective businessperson is well advised to put down a written plan. This is important on many levels. The act of writing a business plan is useful to the entrepreneur in several ways. It causes the writer to focus his/her ideas and energy as well as to clarify the goal and how to track towards it. A well written business plan is critical if you need to attract funds to get the operation started. Investors and bankers need a document to study and to bring before others for analysis and buy-in. Just gotta have it.
Starting a drug company is going to be quite difficult for a few isolated chemists to do. It is a complex and insanely expensive and risky business that requires a wide diversity of players to be on board and committed. Somewhere you have to get an MD or MD/PhD, finance people, former pharma executives, regulatory affairs peoples, etc., on the board to add gravitas to your plan. A whole circus of expensive prima donnas. Sounds like a nightmare to me.
Beyond the horrific reality of the dead and injured in Mumbai from last weeks terrorist attack is the uncertainty of ramped up state tensions between nuclear India and nuclear Pakistan. Pakistani’s weary of home grown terrorists and foreign instigators can sympathize with the fear and revulsion felt by Indians who are stunned by the event. But citizens of Pakistan are indignant about accusations of state involvement in the attack.
Given the weakened condition of the government in Pakistan and the sensitivity from chronic conflict with India, it is hard to draft a rationale describing what benefit the government of Pakistan might have in such dirty dealings.
We must trust that India can take a lesson from US experience with the attack-retribution reflex and find a way to prosecute those who planned this savage crime through police work rather than invasion across borders.
Lamentations on Chemistry 