Memo to Bill Gates

To:  Mr. Bill Gates, Microsoft

Re: Vista

Dear Mr. Gates,

Please set aside an afternoon next week to visit with Th’ Gaussling regarding the new Vista operating system. Also, please bring along a cheque for $150.00 as compensation for brain damage associated with Word document compatibility problems with XP. Oh, we’ll need 2 forms of ID.

Golly, Mr. Wizard.  As planned obsolescence schemes go, this one is a whopper. It’s an upgrade storm that will eventually rain on everyone.  You Microsoft guys are really clever.

Kindest regards,

Th’ Gaussling

Welcome to Taserville, Utah

Every day there seems to be another example of how our disfunctional society is tightening the spiral to chaos. The recent footage of a citizen getting tased by a patrolman in Utah is just the latest log on the fire. In the footage, the trooper stops a driver who then stridently disputes the signage and proclaims his innocence.

He refuses to sign the ticket and is then told to get out of the car by the patrolman. As directed, he walks to the spot where the patrolman asks him to stand. Foolishly, he persists on debating with the patrolman. The patrolman pulls his taser gun and warns the driver to stop and turn around (presumably for a target on the belly). As the driver walks away, the patrolman fires the taser and drops the driver to the ground.

What is troublesome to me is that the patrolman was not being physically threatened by the driver, only ignored. The only apparent risk to the patrolman up to that point was the possibility that the driver would take some time to answer to the patrolmans request. 

I think the driver did not know what kind of peril he was edging towards while attempting to use his “rhetorical skills” to persuade the trooper.

Could it be that the trooper used the taser as a matter of convenience rather than self defense?

Some will advance the argument that troopers are asked to risk their lives daily by pulling over potentially dangerous citizens. They should have this kind of latitude in their judgement calls. But I would say that electrocuting citizens because they are annoying is not a valid response.

What has happened in law enforcement the last decade is the institution of a more militaristic police presence in the USA.  SWAT teams, tasers, armored vehicles, and aggressive tactics all aimed at putting down troublesome citizens.

The whole criminal justice system is out of control. Our failed drug policies and overcrowded prisons are completely ignored by legislators. US drug law only seems to create scarcity and high prices for illicit drugs. It would seem that our puritanical War on Drugs only benefits special interest manufacturers of police equipment, security companies, and private prisons.  

Our prisons have had scant success with rehabilitation and only serve as a brutish, anti-civilizing crime practicum for prisoners. Prisoners are stigmatized with a felony record and consequently barred from most gainful occupations in the US. Why are we dismayed with high recidivism?

Many of my fellow citizens have a mean and brutish side that is not much changed from the days of westward expansion, the Klan, and the Indian wars. Unfortunately, we have a federal administration that is sympathetic to American exceptionalism and manifest destiny through superior firepower. 

We Americans are pretty damned good at demolition. But when it comes to the careful assembly of civilization, we’re bloody cavemen. We confuse the advance of civilization with tax law or better law enforcement. Building a more comprehensive police state is not progress.  It is consolidation of power by paranoid groups who are intolerent of the inherent disorder of pluralist populations.

Chemohaiku

Minty fresh silane

Your smell so sweet, but please don’t

Silanize my brain

Down, angry reflux

There is time for all vapour

to cool, clear and calm

Toluene methyl

Singlet of grief, go away

Without you, I’m done

Chemical Market Echoes

Perhaps the best decision Th’ Gaussling ever made was to stay clear of the pharma business.  In grad school (1980’s), the Standard Model for an ambitious organikker was to work hard in a good group and maybe, hopefully, with any luck, get an interview or two with the big pharma houses. The goal was to land a plum slot in drug discovery with Merck, Glaxo, Pfizer, or several of the other stars in the fabulous constellation of Big Time Drug Discovery.  [Cue Ethel Merman– “There’s no business like pharma business like no business I know !!”]

Most grad school friends have had great success in this field, some are already in director and VP positions. I’m very happy for them.  But I find that I have zero regrets about not going into the drug industry.  It’s not a slam, just a fact.

From my quiet perch behind the curtains, I get to watch a hundred stories play out. Many products that are mind numbingly boring to others are things I know to be the result of difficult and fascinating technology. Elementary things, like the ability to peel off a sticker from its backing is the result of highly engineered materials and processes.

One of the really curious things I see from time to time is what I call a chemical market echo.  Now and then someone will report some work at a conference wherein our product is featured as a key reagent or substrate. Shortly after the attendees get home, there is a flurry of requests for quotation from others in the field. These queries come in from around the world like echoes bouncing off distant objects.

I have seen this numerous times and I am presently in the middle of such a cycle. It is quite gratifying to know that your product has garnered a bit of interest. Unfortunately, penurious professors only order a few tens of grams at a time.

Echoes happen in other ways. If you are in the business of making odd things, a single query will come in from the end user followed by query echoes from others hoping to buy and sell to that single end user. Sometimes the echoes come from competitors hoping to do some sly competitive intelligence work, pretending to be a broker or end user. There are many ways to be lied to in business. All’s fair in love and war. And business is war.

Humble Pie for Chavez, Victory for Czar Putin

There was an outbreak of sensibility in Venezuela this weekend as that swaggering gasbag, Hugo Chavez, was set back in his bid to rewrite the constitution.  Chavez, who was recently and openly told to “shut up” by King Juan Carlos of Spain, has been on a nationalization binge in the last few years. To validate his further consolidation of power, his party attempted to alter the constitution to favor his continued tenure and further his grasp on the resources of the state.  The people of Venezuela told him to go powder his nose.

Things weren’t so democratic in Russia last weekend as a highly managed political campaign delivered the goods. That is, victory for the Party of Vlad Putin, the new Czar of Russia. With key opposition leaders temporarily in jail (Kasparov), and a state controlled media, a comfortable margin of victory was delivered as expected to Putin by his aparachiki. 

Russia’s long, sad history of Big Boss rule continues.

MS Cyborg. Resistance is Futile.

Much has changed in the consumer computer world in the 3 years since I last bought a computer. We recently purchased an HP Pavillion laptop computer. It comes with MS Vista and a bunch of other applications already installed. No program discs or manuals at all. And, like an infant, it pops out gasping for life sustaining air. Only in this case, it gasps for connection to the internet. 

What moves me to write this post is my naive refresher on the extent to which we are becoming enveloped and intertwined by the internet. Increasingly, the internet is becoming the central nervous system of our civilization.

While standing in front of a display at Circuit City I called the HP customer service number to inquire about the warranty on their Pavillion. I eventually spoke with a fast talking character who flat out said that I should not buy from Circuit City, one of their own distributors (!), and that I should have a custom laptop assembled by HP.  After 10 minutes of irritating hard sell, we eventually hung up on him.

This isn’t just about commerce. This is about anthropology. A commercial tool is absolutely altering how we do nearly everything and how we expend scarce resources.  It is a tool that uses features you cannot own- you can only agree to the terms of a license. This tool is held together by the sinew of invisible electronic code. This tool is both pleasurable and fearsome. It can be swung by governments, accountants, and 9 year old Hindu children.

To even inquire about these computer tools, we are forced to use computerized telecommunications and speak to computerized devices that filter and channel us into packing house chutes like pigs to slaughter. This sorting process can identify willing consumers, plump with credit, and prepare them for flensing.

We have become giddy and willing participants in a change that is almost biological in its transformation of our social structure. The very first thing that a MS program wants to do is to connect with the Mother Ship at Microsoft. Increasingly, our DSL connected computers are becoming assimilated into the control of the collective being.  It would be an exaggeration to say that it resembles the Borg of Star Trek. But the idea of assimilation of information flow into a master network is beginning to take shape. A master network suggests master control.

Consumers have control of the situation, you might say. At some level, yes. But there are disturbing trends that need to be recognized.  The playing field of global commerce is neither egalitarian, democratic, or laissez faire. While there may be harmonized regulations that cut across national borders to slow down the more obvious scams, the nature of the players is changing.  Increasingly,  nationalized organizations are participating in the market place in a big way.  In the petroleum market for instance, NOC’s control approximately 75 % of the worlds petroleum reserves. That means that soverign nations can modulate scarcity directly.

Autocratic and paranoid governments do what they have always have done. They restrict access and reduce transparency. When such governments have control of commodity production (i.e., Gazprom), their resilience in the market is magnified by the fact that overhead can be subsidized and scarcity can be driven by politics.  Nationalized commodity suppliers do not suffer the full forces of the market place because they can be floated by the government.  The cleansing effect of the market place on inefficient operation is ineffective.

The openness of the internet can only go one direction. It will increasingly be subject to contrivance and control by organizations that seek facile extraction of dollars from you. Today, buying a computer means giving increasing consent to automated integration into the net.  We willingly comply because we are first and foremost primates who are dazzled by flashing lights, pretty colors, and a new axe to swing around.

Uncle Merck and Aunt Lilly

According to the November 26, 2007 C&EN, Merck has for a second time engaged the Indian firm NPIL to develop cancer drugs for two targets that they have disclosed. Merck will have the option to buy rights to the compounds, providing they successfully get through Phase IIa of clinical trials. The article discloses that Eli Lilly has made a similar agreement.

It is disappointing to see companys like Merck and Lilly outsourcing their R&D. I do not intend to besmirch NPIL. They have obviously crossed a threshold in their own R&D activity that meets the standard of major league pharma. But I do believe that Merck and Lilly deserve some scolding for outsourcing R&D.

R&D is one of the remaining activities for which the US maintains a bit of an edge. It is our magic.  To accelerate the development of R&D expertise in India is to act against our self interest as a country. India will eventually develop this capability on their own- why help? Drug discovery is an art that should be jealously guarded by a company. To farm it out to a hard working developing country with lower overhead rates is ultimately foolhardy. Even though some particular art is protected, this activity is always stimulates a company.

Lucky India. They get to exploit advanced technology without having to have paid for 100 years of R&D. Instead of having to pay to develop synthetic chemistry, they can plug and chug with a newly educated populace and access to the literature.

And who paid for the universities and the NIH post-doctoral fellowships and the research assistantships for grad students who developed and published the technology and who became the scientists whom Merck hired? Take a guess.

Investors may reap near term gains and Merck may get a better market foothold in India. Some executives will look like bloody geniuses. The presidents and CEO will prattle on over brunch about bringing home shareholder value. But when R&D goes the way of garment manufacture and automobiles, these “heroes” will be retired to their gated community in Palm Springs. In the end, they have eroded the competitiveness of the USA in an aggressive and contentious market.

Thumbs down to Merck and Lilly.

Person of Gender

Some years ago, my first real job out of my post-doc was a one year teaching stint at a Catholic womens college.  The post-doc was rather less than a great experience. But that is a post for another time. I did get a couple of JACS papers, a Mendeleev Communications paper, a divorce, and one Org Synth publication out of it. And, I got to work with some smart folks I still consider to be among my closest friends.

The post-doc years were a time of deep personal turmoil. The divorce was traumatic. It affects one in ways that are hard to appreciate in advance. Mostly, it presents an indelible stamp of failure to the bearer.  If it weren’t for friends that I made while in Texas, frankly I don’t know where I’d be today.  The adage “What doesn’t kill you makes you stronger” does have some truth in it.

The Catholic school I taught in was associated with a major football presence in the midwest. The womens college was run by the same group of nuns who were connected with the coed university across the street so venerated by football enthsiasts. It had its own exit from the toll road, two lakes, two golf courses, and a mosaic of the Saviour declaring a touchdown. 

I bought furniture from Father Clarence and slept on a priest bed (without the priest, blessedly) for my academic year under the employ of nuns. Such furniture was typically donated back for eventual resale. Father Clarence offered to sell me the two 35 mm projectors used to entertain the revered Four Horsemen. Like an idiot, I declined his offer and regret it to this day.

The nuns who ran this single gender institution were an aging population. Initiates were hard to find- apparently most came from South America. The Blessed Sisters eventually handed off the university so they could concentrate on their hospitals.

Even though I received paychecks from the Sisters, I rarely saw them. We did have a nun from a different order in our department.  She was a pistol. And a biochemist. Her interest was infecting caterpillars with deadly caterpillar viruses. Strange game, this. Our Dean was a hoot- she looked and sounded just like Ethel Merman.

I taught a class of 95 students, all women. I recall looking out into a crowd of 19-22 year old women, most with poney tails protruding out from the back of baseball caps and peering at me under bills that were severely curled.   It was a general chemistry for non-majors section populated by students who couldn’t get into biology or the popular “physics for poets” class. These hapless students ended up with me as a prof.  What rotten luck.

One morning driving into work I was in a serious auto accident where I nearly rolled over my pickup. The patrolman graciously dropped me off at the college where I ran to the classroom 10 minutes late. Not a single one of the vicious little trolls waited for me to arrive. (After all, it says somewhere in the new testament that a student only has to wait 5 minutes for the prof.)

I took over a class previously taught by a fellow who had just died. His office was closed and untouched by a disinterested family. It was an odd experience- he was fresh in everyones mind except for mine. 

The main recollection I have from the experience is that perhaps 1/3 of the students I knew were genuinely dismayed that men taught at the University. They would point out that it made no sense for a women’s institution to have male faculty. As a “person of gender”, it was hard for me to disagree. But I would also point out that of the remaining 2/3 that I spoke with, half were uncertain about the wisdom of attending an all womens institution. So, for me it is hard to draw conclusions about the merit of single gender institutions. From a marketing view, there is/was demand for this kind of school. But whether demand is from parents or students is less clear to me.