Category Archives: Science Education

Aldrichimica Acta, Vol. 42, No. 2, 2008.

The latest Aldrichimica Acta is out- No. 2 of volume 41. This publication was started by a friend, teaching colleague, mentor, and former boss who spent some of his best years working for Alfred Bader. He eventually retired as a VP of something or other at Aldrich. A truly great guy. For a while, the task of catalog publishing was his job. He bought paper by the rail car. Their job was to increase the size of the collection by 15 % per year.

He also invented the coffee pot kugelrohr system that Aldrich sold for a long time. It has now morphed out of recognition. But he showed me the prototype motor assembly. It consisted of a reciprocating air motor built for automotive windshield wipers wired onto some pegboard. The air motor used either air pressure or vacuum and had a metal tube that connected the vac line from one side of the motor axially to the other.  The reciprocating motor got around the need for a sealed vacuum bearing. To one side of the reciprocating tube was connected a vacuum line via flexible rubber hose, and to the other via hose and barbed connector, a series of bulb tubes and pot. 

The coffee pot came from a West Bend coffee pot plant down the road in Milwaukee. Aldrich bought the reject pots and paid a guy to refit them for kugelrohr duty in his garage. It was a very successful product. When I went to grad school we had a Buchi kugelrohr for bulb-to-bulb short path distillation. But I still remember with some fondness having to sit at the bench twiddling the Aldrich kugelrohr by hand while feeding dry ice onto the receiver. Sometimes we would drip dichloromethane in the receiver and let the evaporative cooling do the trick. We’d use the air motor for lengthy distillations.

Organic and Inorganic Carbon??

Thanks to a friend in Grand Rapids, I was linked to a blog hosted by the NY Times called Tierneylab.com.  The writer of the post was sounding off about a pet peeve relating to the use of the term “Organic”.  It seems that there is some confusion as to the use of the adjective organic in relation to certain carbon-containing substances. Tempest in a teapot, you ask? Let the chemistry community decide.

The problem begins to show itself when astronomers and planetary scientists start describing carbon containing materials found in planetary exploration as organic.  Back on earth, the word organic is burdened with both common and scientific usage. So, when descriptions of organic materials found on other worlds begin to arise in discourse, the intent of the usage becomes unclear.

For instance, it could suggest to people that such discovered materials were put in place by some kind of life form. It could suggest to nondiscriminating audiences that the presence of carbon implies life, past, present, or future. Or it might well suggest to higher level audiences that biology-ready raw materials are in place.

The scientists working with the Phoenix Lander have an interesting analytical chore in front of them. Using a robotic platform on Mars, they want to distinguish the presence of organic vs inorganic carbon. What is meant by organic and inorganic is less than clear. But it seems that organic refers to something other than CO2 and carbonate.

In the relatively few journal articles I’ve seen relating to this, the authors are not always precise about the kinds of molecules they are referring to as organic. Irrespective of what is said in the articles, when this work gets to a public forum, the meaning behind the word organic becomes even less clear.   

The TierneyLab post does bring up an interesting question about what is necessary for a substance to be considered organic.  Do graphite, diamond, Buckyball, or soot forms of carbon qualify as organic? What about CO2, CS2, carbonates, CO, HCN, or calcium carbide? Does it make more sense to refer to organic and inorganic carbon, where inorganic carbon is defined as … well, what? 

Seriously, what would it be? CO2? Carbon dioxide is incorporated into glucose by plants and this seems quite organic.  Carbonate? This anion is used to balance our blood pH. Our own metabolic CO2 helps to provide carbonate. This product of metabolism should qualify as organic. CO? Well, Carbon monoxide undergoes Fischer-Tropsch reactions to produce aldehydes. This seems very organic as well. Perhaps the target is a substance with C-H bonds?

There is nothing inherently biological about the C-H bond. The Saturnian moon Titan is blanketed with a thick layer of CH4 (methane) and it seems unlikely that it is of biological origin. Indeed, hydrogen is the most abundant element in the universe and carbon the 4th. That hydrogen and carbon atoms could find each other to form trace methane in a proto solar system isn’t too much of a stretch.

Organic and Inorganic Carbon.  How about we just leave it all as organic? 

Here is what I think. It does matter if a scientist or writer is using language in an imprecise way. If writing or speech implies, for instance, that Mars is rich in life giving organic nutrients when in fact Martian organic matter is really carbonate and CO2, then I believe the language must be altered to reflect that condition. A writer should not leave an impression of past or incipient planetary fecundity when in fact the planet may be an inert ball of metal silicates dusted with a bit of carbonate when the 6 torr CO2 atmosphere kicks up a breeze.

How to pass organic chemistry

WordPress shows the blogger what search terms lead the searcher to your blog. One of the searches that lead a reader to this blog was “How to pass organic chemistry”.  Here is my answer-

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My dinner with a meteorite

Last night I found myself sitting at a restaurant with astronomers for the occasion of viewing a meteorite. Customarily, a few observatory folk have dinner with the speaker and then we go to the observatory for a public star night. While waiting for our entrees we passed the object carefully amongst ourselves, cherishing a few moments of close contact with this rare object.

Astronomers seem to be prone to public displays of humility. I would estimate that the humility quotient was near 0.8 (8 out of 10 Sagans- the Sagan is the international unit of humility). It is generally agreed that the Buddha achieved a Sagan quotient of unity. Okay, I’m kidding.

The curious 936 gram achondrite is from the recent Berthoud, Colorado, fall.  Meteor enthusiasts refer to the arrival of a meteorite as a “fall”.  This is one of only 5 witnessed falls in Colorado. A section of the meteor has been cut off and has been the subject of investigation at the University of Arizona.

Based on the composition of the object (olivine, plagioclase, ilmenite, chromite) and based on the reflectance spectra of various asteroids, the Berthoud meteorite is thought to be a fragment of the asteroid Vesta. Imagery of Vesta suggests that a portion of this object may have been shattered by an impact in the past.

The family whose property the stone landed on are somewhat bewildered by the event. They have been the subject of much unwanted attention, so the object is kept secure at an unknown location. In October of 2004, in the early afternoon several family members were standing outside their home when they heard a whistling sound and thump. Following the direction of the sound, they found the impact site less than 100 feet from where they were standing and in a spot where one member had just walked through. Only a small part of the object protruded upward through the disturbed topsoil.

Reportedly, it was cool to the touch immediately after arrival. This is counter-intuitive given the fiery appearance of most meteors. However, the object was quite cold prior to entry into the atmosphere and the rapid transit through the air didn’t allow for heat saturation. And, ablation carries away much of the friction energy.

The low iron object has a dark fusion crust over a grey, mottled composition. Other than the crust, it is not that unusual in its appearance. 

 

Chemists and Engineers

What would happen to innovation in chemical technology if we had a more intimate comingling of chemistry and the engineering sciences?  What effect would there be on the stream of chemists graduating into the world if more schools had a chemical engineer on the chemistry faculty? Could a single engineer on the faculty actually make a difference in altering the direction of the boat a few degrees?

Why is such a change desirable? One way to change the trend of deindustrialization and economic repositioning of manufacturing out of North America is to stimulate innovation in the industrial sciences. To do this we can rely on business leaders individually to formulate strategic plans to upgrade plants and processes by way of step changes in technology. But for business leaders, the calculation for such a change must also take into account the alternative of moving production to another country. Many times it is easier and faster to move production to China rather than taking a gamble on the invention of better technology. A large amount of pharmaceutical manufacturing has been shifted to China, Mexico, and India for this very reason.

To rely on business leaders (top down) to ramp up innovation really means that one is relying on the market. While letting the marketplace drive the economics and distribution of manufacturing has a certain appeal to purists, the global marketplace is highly distorted by government and taxation. Letting “pure” market forces govern innovation as the sole driver is to bet all of your money on a horse that limps.  Why not find ways to stimulate innovation with an improved stream of chemical innovators and a renewed urgency?

Universities do this all of the time. But it is my sense that other disciplines perhaps do this better. It is all too easy for we chemists to invent a reaction or composition, publish it, and then move on to the next outcropping of opportunity. We do this thinking that surely somebody will pick up the ball and run it to the end zone of commerce.

But for any given paper published in SynLett or JOC or ______, the likelihood of commercialization is low. It is not automatically the role of academic science to drive its work towards commercialization. That has been the role of engineering. 

What has been lacking is more significant early overlap of the two disciplines. For a chemist to truly be a part of bringing a transformation to the manufacturing scale, the chemist has to begin thinking about how to prepare the chemistry for the big pots and pans. This is what the art of scale-up is about. And in scale-up, the practice of chemistry has to overlap with the practice of engineering.

Industry already provides for itself in this way by training chemists to do scale-up work. This kind of work has always been beyond the scope of academic training.  But what if there were a course of study wherein chemistry faculty and students could more thoroughly address the problems of chemical manufacture? What if engineering concepts would be allowed to creep into the training of chemists?

Chemistry faculty would begin writing grants for process oriented research. Schools without engineering departments might start hiring the odd engineer or two in an effort to “modernize” the chemistry department.  Gradually, a department might become known among recruiters and donors for producing a strain of BS, MS, and PhD chemists who are already adapted to process research.

It is important to stress that the goal is not to plop conventional engineering curriculum into the chemical course of study.  That will not work. But what is possible is to build a minor in industrial chemistry applications. This pill will be easier to swallow for the P-chemists because in short order it would be apparent that chemical engineering is heavily loaded with physical chemistry.

I have tried to make a case that one way to make a positive influence in chemical innovation in North America is to begin a grass-roots effort to stimulate the culture of chemistry. I believe that providing an avenue of study that includes early exposure to engineering and process economics will stimulate many more students and faculty to make significant contributions to entrepreneurism and industry.

The Chemistry Curriculum

It is time to have a frank talk about the fundamental merits of the college chemistry curriculum. This plan of study has remained substantially unchanged for decades (see comment by bchem). Certainly minor changes occur through nudges and bumps here and there pertaining to details. But in the last generation has there been a dialog or debate on the fundamental assumptions of the common curriculum? And I refer specifically to the ACS certified curriculum, which has been the gold standard across the country. Major changes that I have been witness to mainly accomodate an increased emphasis on biochemistry or new computerized instrumentation. 

The undergraduate chemistry curriculum is a very logical and thorough survey of the three pillars of chemistry- Theory, synthesis, and analysis. This covers the fields of inorganic, organic, physical, analytical, and biochemistry. Along the way we teach a few other areas of specialty by way of electives.

The current program of chemical pedagogy is certainly true to itself. There is genuine concern and care to avoid dilution of the content and over-inflation of grades, generally. The core domains of the subject are sorted out and given special consideration. Much work has been done to spark interest in the field and textbooks seem to be written quite well as a rule.  Resources like J. Chem. Ed. are a continuous stream of clever tools and tricks to make the subject more plain.

Our colleges and universities have been quite good at churning out chemical scholarship. And students are given scholarly exposure in their learning program. Not surprisingly, scholars are very good at producing more scholars.

But has the academy been keeping up with the role of chemistry in the world?  Just look around. How many CEO’s and upper executives in the top 100 chemical companies are chemists? I have not seen this statistic tabulated. But I am confident that relatively few chemists populate those ranks. Those that do often arise through marketing or finance channels.

But why should they? The field of chemistry attracts people interested in science, not business. Chemical educators have a responsibility to educate chemical scientists with a minimum proficiency in the field.  That requires a minimum number of semester hours of coursework within a 4 year period. There is only so much a department can do and so much a student can absorb.

Yet, the purpose of a college education is to prepare a student for a productive life. A learning program that is internally consistent but blind to the needs of the external world is a fantasy. Have we come to value programmatic tidiness more than practicality?

Chemistry is a highly practical field. It involves problem solving and production. Chemists make stuff. Chemists solve problems. Chemists are specialists in the transformation of matter. But chemists do not operate in a vacuum. They do their work for organizations, and there is the rub.

By training, chemists are woefully prepared to function outside the laboratory. And as a direct result, chemists are poorly prepared to leave the lab and function elsewhere in the organization.  Traditionally, education in the organizational arts has been considered on-the-job training. In a sense this is not unreasonable. How can educators anticipate the needs of a student 5 years into the future? 

What is under appreciated by educators and students alike are the many opportunities that will follow for a chemist in industry. Many if not most chemists will come to a fork in the road in their careers. Will they stay in the lab or will they go to the business side? Usually, the path to greater opportunity in a business organization is the business side. Technical sales, customer service, marketing, procurement, management, etc.

I am not proposing that chemistry faculty teach coursework that cover such material. I am trying to suggest, however, that chemistry departments take a closer look at what an industrial career really looks like and try to anticipate a few needs that will arise as a result of this career path. Advisors can talk to students about the possibility of a business minor. An accounting or marketing class could be very helpful for a student who is uncertain about his/her career path. These are painless actions that can be of great use to a graduate.

But there is more than the passive approach of suggesting alternatives to undergrads. There is a more active approach that would definitely serve the needs of students and society alike.

Elective coursework covering intellectual property and patents, business law, the regulatory world (TSCA, EPA, OSHA, CERCLA, REACH, etc.), industrial hygiene, and perhaps most importantly an introduction to chemical engineering. This last item I cannot overemphasize.  Chemical engineering includes the basics of unit operations, process economics, thermodynamics, and controls. I would offer that the whole package could be called Industrial Chemistry. 

There are junior college programs for chemical operators that do provide exposure to some engineering concepts. But this isn’t necessarily for management track graduates.

I would offer that the department with an industrial chemistry program would be very successful in job placement as well as attracting new majors.  Comments?

 

Solar Warming

Here is an interesting analysis of solar min/max data. I can’t vouch for the kind of analysis that was performed. But it is interesting to see. The effects of variations in the solar flux on global temperatures seems to be neglected in discussions I run into. Among other things, these folks suggest that a lesser known 66 year solar cycle may come into play.

One commentor in a previous post suggested that we are approaching the end of the current interglacial period. He said that recent interglacial periods were characterized by polar cap melting followed by entry into the glacial side of the cycle.

Even if the solar output was constant, the interplay of the ocean heat reservoir with the atmosphere, greenhouse gases, vulcanism, asteroids, and the earth’s albedo is complex enough.  Heap on top of that the subtle thermal modulation by the sun and you have a really complex problem.

Global warming could reduce to an equation where one of the components of the sum derives from anthropogenic greenhouse emissions. 

I keep having this thought that Al Gore is eventually going to have a long talk with Tipper about returning the medal to Sweden.

NIH Manditory Open Access

According to C&EN, the NIH has issued a rule that publications resulting from NIH funded research be submitted to PubMed Central for posting.  Naturally, organizations with copyright interest in published research is  less than enthused by this ruling.

What has happened over the last century is that a sizeable publishing industry has grown up around the publication of periodicals specializing in scientific research.  In exchange for release of copyrights, authors get free or nominally priced access to publishing and distribution of their work. For their part, publishers tap into a continuous stream of refreshed content that is virtually free of charge. 

Counterbalancing the low cost of content are the sad facts of subscriptions.  Many (most) journals suffer from low distribution numbers, so the zero cost of content helps to keep overhead down, but publishing and distribution costs cannot benefit from the economy of scale.

The special interests seem to be sitting in watchful waiting, but they have raised the issue of copyright. Their concern is that they are being forced to distribute their property by the strong arm of NIH without the chance for reimbursement.  This could resolve to a property rights battle and as such, I can’t imagine that the NIH would prevail in the courts.

Descriptive Inorganic Chemistry

Now that I am doing a fair amount of inorganic synthesis and preparation of metal coordination complexes, I look back to my undergraduate education and wish that it had been somewhat different.

In my undergrad time in the early 80’s, inorganic texts were heavy in theoretical concepts- molecular spectroscopy, ligand field theory, and group theory. It made for a tidy textbook package and coursework was constructed around it.  I cannot speak for other institutions, but in my experience the inorganic curriculum is (was) somewhat leaner in course options than is organic or biochemistry. In particular, the inorganic lab experience was somewhat less endowed with resources than the more popular biochemistry lab.

In graduate school, our graduate level inorganic coursework was even more theoretical than was the undergrad coursework. Obviously, there is a good argument for this and I am not actually complaining about it. But I will say that, in my experience, descriptive inorganic chemistry in the lecture section was sacrificed by the professors apparent preference for the elegance and tidiness of theoretical inorganic chemistry.

To his credit, my undergrad inorganic professor did try to give us the best lab experience possible. We had a vacuum line and did have the chance to use it. We did a prepn of AlI3 a tube furnace. We prepared Cu2(OAc)4 and a few other complexes.  He was also a glass blower  and did his best to teach us a bit about glass.

But in the end, the department was much more highly invested in organic and biochemistry. I was enchanted by synthetic organic chemistry and continued down that track.

With the benefit of hindsight, I now see that the curriculum that I was channeled through was too lean with respect to the rest of the periodic table.  Decriptive and  preparative inorganic chemistry was wedged in only by virtue of the strength of the professors interests and personality. Theoretical inorganic chemistry does not require expensive laboratory facilities.

So, I have come out to speak in favor of more descriptive inorganic chemistry in the curriculum.  More reaction chemistry. More preparation of materials in the lab. More characterization of or reaction products. More experience with setting up reactions and isolations.  More experience with hazardous materials!!

The notion that laboratory experiences for chemistry majors must be constrained by the need for Green consideration is nonsense.

I believe that microscale equipment for chemistry majors should be banned. Students should minimally prepare a few grams of materials so that they can be handled for subsequent purification and characterization. Forcing inexperienced students to prepare a spatula tip of product is unfair and needlessly harsh.

The idea that constraining a junior or senior to preparing less than 100 mg of product in a reaction is somehow green and worthy of merit is absolutely ridiculous. This is chemistry lab, not church camp.  The savings in environmental insult is minimal. There are much bigger fish to fry than this anyway. 

I suspect that equipment expenses and waste costs for university chemistry departments are drivers in what is chosen for the lab experience. If indeed efforts are being thrown on better instrumental experiences rather than better preparatory experiences, then I would say that we are missing the point. Given the creeping featurism in computer controlled instrumentation, I would suggest that monies be spent on better synthetic experiences than on the latest hyphenated instrument. 

Perhaps someone could comment on this.

Farewell to Arthur C. Clark

I’m saddened by the recent passage of the science and science fiction (SF) writer Arthur C. Clark. I blundered into the SF works of Clark, Asimov, and a few others as a high school sophomore. Freshly relocated from the midwest in 1971, I fell into a social group that was largely scientifically and technically oriented. We shunned hippies, pot, and cigarettes in favor of electronics, SF, chess, and physics.  We were juvenile scientists and engineers.

I have always enjoyed the narrative style of Clark. He was able to write thought provoking SF with dialog that was comfortable yet focused. He could manage plot development with technical subjects without collapse into a pedantic or evangelical tone.

What I am left with from my years of reading SF is a particular world view.  My vision of the future is greatly shaped by numerous SF stories written over the last 75 years. It is an egalitarian world where people have reasoned their way around nuclear self-immolation. A world where the quest for knowledge is prized and where the extinguishment of pain and suffering is sought by all. Greed has been abandoned as a way of life.  People spend the bulk of their lives seeking pleasure and understanding, not just the next meal.

But, it’s just science fiction.