Category Archives: Science

Is Private Sector Buggery Better than Gov’t Incompetence?

Healthcare in the USA is wildly expensive and is growing more so at a rate that exceeds inflation. This is well known. The battle for healthcare reform in DC is bogging down under the weight of private interests and infighting.  Soaring rhetoric from both left and right is mistaken for intellection and reason. It is evident that the fix to the problem was started before there was a clear understanding of the variables.

If you look at healthcare as a manufacturing activity with labor, capital equipment, and materials as input and some sort of health benefit as the output, you can start to see what cost inputs may begin to dominate. Of course this is very simplistic, but hang with me.

A round of health care involves attention by highly trained and expensive labor. A health care worker can only attend to one person at a time, though that worker may have many patients under his/her supervision. If a patient is stabilized, the care worker can also attend to other patients and achieve some sort of parallel production for better cost containment. In the heirarchy of medicine, the docs are managers who provide oversight to nurses who manage the patients. Docs also do consultations, examinations, and perform surgery, so they are not pure people managers- they get their hands dirty. Docs are a unique class of management all by themselves.

To exaggerate the effects of labor costs, imagine if you had a doc or a nurse picking strawberries, how expensive would the strawberries be? Even if Dr. Picker was very fast, the berries would be expensive. To have reasonably priced berries you have to find workers who will do the work at a lower wage. Lower wages derive from an abundance of willing labor.

In the end, medical schools control the scarcity of physicians by controlling enrollment. And the enrollment is defined by the curriculum, faculty size, and the particulars of the coursework- availability of clinical experiences, lab space, equipment, etc. But, you have to wonder what would happen to medical costs if there was less labor scarcity.

The most important resource a medical school has, other than faculty, might be the university hospital. What if more hospitals had medical schools rather than the other way around? I don’t think that the existing medical schools have absorbed all of the bright candidates out there.

Health care is a kind of economic chimera. The recipient of medical treatment is not the person in control of the costs. Physicians prescribe the type and extent of resources and the insurance companies release the funds. The medical establishment receives payment for services irrespective of outcome. Insurance companies profit by denial of services. The patient is left to sort out how to get the best value from available treatment.

American medicine is very much influenced by technological triumphalism.  New and expensive materials and devices hit the market all of the time. The question every potential marketer of medically related items must ask is- will the docs use or prescribe it? The most powerful instrument in medicine is the physician’s pen. The question for drug and equipment makers is, how do you get the docs to use their pens to your advantage?

The view that a disease or an injury is a sales opportunity is what drives for-profit clinics and hospitals. Without chronic disease, accidents, and sporadic outbreaks of mayhem, growth and profit in the healthcare industry might be more static.

So in the end, who do you trust? Do you put your faith in the private sector whose avowed goal is to profit on your illness? Or do you trust the government which, though accountable to its citizens, is prone to profound organizational inertia and a lackluster draw to talented staff?  This is the balance of opposing forces the fools in Washington are trying to sort out. Howard help us all.

Bruker’s New 1 Gigahertz NMR Spectrometer

June 1, 2009, Bruker announced the release of the AVANCE 1000 NMR Spectrometer. This 1000 MHz (1 GHz) instrument features a standard 54 mm bore within a 23.5 Tesla superconducting magnet. The magnet technology offers subcooling (below the bp of He) in the magnet, which Bruker claims to be necessary for the stability of the magnetic field. Bruker also offers nitrogen-free magnets that are able to keep the helium boil-off rates to a minimum. While it would be nice to avoid having to manage two cryogenic liquids, I wonder what the pay-back time is for the chiller equipment?

Imagine the hassles, begging, and incredulous stares that the users will have to contend with to to get some 1 GHz NMR time? I wonder if anyone will do 1-D experiments with it?

The AVANCE  1 GHz instrument is priced at a cryogenic ~$16,000,000 per copy with an 18-24 month lead time. I’ll have to stick with Anasazi Instruments for a while at least.

Separately, a link at the Bruker website will take you to the University of York where a site dedicated to one groups NMR work with parahydrogen is detailed. A technique called SABRE, Signal Amplification by Reversable Exchange, is described. The exposure of an NMR sample to parahydrogen (singlet H2) results in the transfer of polarization to the sample and subsequent increase in sensitivity.

The workers describe the operation of a device used for the conversion of triplet orthohydrogen to singlet parahydrogen as a ready source of this peculiar “isomer” of dihydrogen. Parahydrogen is the dominant form at 20 K, but drops to 25 % abundance at room temperature. Exposure of a mixture of ortho and parahydrogen to a paramagnetic catalyst does the conversion to achieve enriched singlet H2.

According to one on-line source, the conversion of ortho- to parahydrogen evolves 527 kJ/kg. I’d watch out.

July Lenticular Clouds

Warmer weather in Colorado brings cloud formations that are characteristic to the summer season. Summer in the Colorado front range typically brings convective activity that boils up cumuloform clouds, some of which accelerate into anvil shaped storm cells that bring rain and hail.

What are not often seen in the summer, at least for a hack weather observer like Th’ Gaussling, are lenticular clouds. These are characteristic of the cooler seasons. Indeed, since I have been following weather here (late 1970’s), I have never witnessed lenticular clouds in July, at least until yesterday. Very curious.

Proterozoic Contact

My search continued today for an exposed contact between the upthrusted proterozoic igneous rock of the Rock Mountains and the Fountain sandstone formation. I returned to an obscure roadcut site I had examined a few months ago. Three (male) cyclists outfitted in expensive cycling couture (Spandex) were standing there nibbling on dainty little energy snacks next to the spot I needed to be as I pulled up and exited my vehicle with a rock hammer in hand. One seemed taken aback momentarily as I walked towards them with the chisled masonry hammer. It didn’t dawn on me until after they left why they were acting strangely- I startled them. Sorry fellas!  \;-)

With rock hammer in hand I scrambled up a steep and unstable scree slope adjacent to what appeared to be disturbed layer next to a gneiss formation. Down below, along the roadcut, a contact was visible between the gneiss and what appeared to be schist.  This dark material has a preponderance of mica with little gross evidence of stratification. I wrongly concluded that I was not near the proterozoic contact.

But as I followed this discontinuity further up the mountain I found clear evidence of a stratified sedimentary formation adjacent to the igneous rock. On a ledge high above the road I found an actual contact between what appears to be modified sandstone and gneiss. I found a sample that has the gneiss fused onto the layered rock that fractures into thin sheets much like sandstone or shale. Regrettably, I left the camera in the Jeep.

What appears to have happened is that the sandstone layer has been thermally modified along the interface due to the intimate contact with the upthrusted igneous rock. I had half-expected to see a simple interface between sandstone and an igneous rock. Instead, what I seem to be seeing at this site is a modified sedimentary layer that shows evidence of some localized metamorphic modification.

A nearby thin layer of rock in the interface zone appears to be glassy or vitrified, as though it has been partially melted. I do not interpret this to be a result of weathering. A rapidly approaching lightning storm forced me to cut my exploration short and run for cover.

So, I have some hypotheses beginning to take shape. Now the question is, how do I falsify my interpretations? I certainly have much to learn about petrology.

National Organic Symposium. Wender Wednesday.

My final attendance at the National Organic Symposium was Wednesday evening. An award was presented to editor-in-chief, Scott Denmark, on behalf of the monograph series Organic Reactions. The original editor was none other than Roger Adams. Denmark presented a retrospective slide show on the history of Organic Reations.

The speaker for the evening was Prof. Paul Wender from Stanford.  Wender presented a long but fascinating talk on his work with several complex molecules including bryostatin. I have to say that I was rather blown away by this work. I guess I’ve been living on a desert island.

Wender has the great fortune of having access to facilities and people who can do complex chemical synthesis and biological assays and all of the other wondrous things that are necessary to rapidly expose a valuable biopharmaceuticals. The payoff is that questions relating to the biological activity of particular derivatives can be answered rapidly and productive leads can be isolated and further cultivated.

This confederation of resources is perhaps as important to Wender’s productivity as anything. My point is that to be a Wender, you need more than just smarts and money. You need a network of like-minded coworkers whose particular strengths can mesh with yours to produce these kinds of results.  I think that his ability to pull together these kinds of resources is just as impressive as his native ability with chemistry.

National Organic Symposium. Tuesday Morning.

Bad day for Th’ Gaussling to be away. The hounds are snapping at my heels at work.

I managed only to see Eric Jacobsen‘s talk on catalytic urea chemistry. Jacobsen’s system is pretty much a chiral proton ligand that can carry along a nucleophilic counter anion. Configured differently, urea’s and thiourea’s with BARF groups on the nitrogen can coordinate with chloride. This can lead to the abstraction of chloride to give a carbenium ion that can then participate in a enantioselective Pictet-Spengler type reaction. 

Jacobsen’s system resembles a radically stripped down enzyme in terms of 3-point binding interactions by hydrogen bonding.  Where Jacobsen went askew is the use of calculations to justify his mechanistic model. The models did not include solvent interactions when affording only 0-2 kcal/mol (!!) differences in energy. Naturally this did not set well with certain distinguished members of the Audience.  The ΔΔG’s did not correlate with the ee’s at all either.

A certain J.D. Roberts took great exception to Jacobsen’s molecular modeling results, resulting in the spectacle of a Harvard Professor frantically qualifying his slides and words as he back pedalled for all he was worth. There was some actual contrition there on the stage. It was quite a thing to see. There but for the grace of God go I.

Organic Symposium

Despite my previous gritching about it and despite trying to stay below the radar at work, the boss has requested and required that I attend the Organic Symposium at CU Boulder. I’ll bop over there later today to register and walk the poster session. Maybe there will be some useful grist for the blogmill.

No better reminder of the scientific pecking order than to skuttle around in the shadows of the great grant writers of our time. A certain speaker with a Nobel Prize casts a shadow so large that it is reported to weigh nearly 5 kilograms. Fancy that!

May Linkfest

A friend sent me the link to Wolfram|Alpha  just a while ago. So far it seems to be a bit lean in textbook-style content in the chemistry area. For instance, when you enter “aromatic solvents” into the dialog box, it returns with

Wolfram|Alpha isn’t sure what to do with your input.

But if you type in “toluene”, suddenly it is the CRC and is flush with data. The stated goals of the Wolfram|Alpha developers are-

Wolfram|Alpha’s long-term goal is to make all systematic knowledge immediately computable and accessible to everyone. We aim to collect and curate all objective data; implement every known model, method, and algorithm; and make it possible to compute whatever can be computed about anything. Our goal is to build on the achievements of science and other systematizations of knowledge to provide a single source that can be relied on by everyone for definitive answers to factual queries.

I do not yet know enough about this resource, but it seems to be a data engine rather than a prose engine.

Landscheidt Cycles Research is a site devoted to the Planetary Influence Theory. This theory pertains to the possible gravitational influence of the planets on solar cycles. it is worth a look.

Watts Up With That? is a blog concerned with global climate issues. The blogger and many of the commentors seem to have their facts straight about global climate change. The site is very data intensive.

If you are a scientist or manage scientists, it is worth considering the file drawer effect.

An online NMR predictor can be found at nmrdb. In my experience the splitting and chemical shifts seem to be in the “not too awful” range.

Biohackers

A recent article in the WSJ solemnly described several amateur biologists who were doing simple molecular biology experiments in their homes. Naturally, this has not escaped the attention of certain authorities and certain deeply conservative establishment news corporations.

What is distressing is the reflexive conclusion that their activity is automatically dangerous and likely to be symptomatic of malevolent intent.  It is common for those in power to look over their ramparts and view the world as a spectrum of threats. And so it is in this case that distrust has arisen and reporters are using the words “weapons of mass destruction” or “ebola virus”. 

Could it not be that some people outside of the heavily in-bred fields of science have a genuine and scholarly interest in molecular biology but no interest in grad school?

The entrance to scientific activity is highly formalized with layers of degree requirements, preferred pedigree, institutional infrastructure, regulatory complications, and a mafia-like oligarchy that disperses the resources and opportunity that is so necessary for buoyancy in science.

How does a creative amateur scientist get to take a jouney of discovery in a field that is institutionally inaccessible to them? And how does an interested individual who is clever enough to conduct experiments deal with a government whose reflex is to see WMD and terrorists behind every lilac bush? There are serious civil liberties problems here that pit the brain stem against the frontal cortex.

It is in the nature of some people to be distrustful and find threats behind every shrub. It has been my observation that people who default into a distrustful posture are very often not trustworthy themselves. The distrustful often invoke slippery slope arguments as rhetorical devices to block their opponents move into new conceptual turf. What the distrustful and paranoid fail to see is that we live every minute of every day on multiple slippery slopes, yet we somehow survive and thrive.

Cresson Gold Mine, Part 1.

Early saturday morning 50 intrepid geotouristas packed into vans and drove to the CC&V mine in the Cripple Creek district of Colorado. Most of the group were professional geologists- professors, teachers, and geological survey folks. There were only a few interlopers like myself who were interested but untrained in geology. Not surprisingly, a background in chemistry is nearly useless when the discussion turns to stratigraphy and rock morphology.

The Cripple Creek gold district consists of an extinct volcanic structure called a diatreme. A diatreme is characterized by the presence of a volcanic pipe structure filled with brecciated rock. It is thought that the combination of shallow hot rock and ground water lead to violent explosions that resulted in fractured rock. Cripple Creek breccia has rounded clasts, indicating the rock fragments were exposed to rough, erosive treatment leading to attrition and rounding of the clasts prior to consolidation of the breccia.

In the past, gold mining at Cripple Creek was a underground activity. The district contains an extensive network of remnant subsurface works of drifts and shafts. Today, CC&V’s mining activity is limited to high throughput open pit excavation supplying pulverized rock to a cyanide heap leach field. A constant flow of ca 100 ppm aqueous sodium cyanide solution is leached from the top down through as much as 800 vertical ft of gold bearing rubble.

Abandoned Drift and Blue Bird Dike

Abandoned Drift and Blue Bird Dike

Columnar formations can be seen in certain locations of the mine (See photo: some features are enhanced with lines to show the margins). As the pit expands, drifts and shafts are exposed as seen in the photo above. The Blue Bird dike is an igneous intrusion into the surrounding formation. It is no coincidence that the drift in the photo is near the dike. It is common to see disturbed zones along the intrusion where gold can be found in higher abundance. The goal of the drift miner was to follow the enriched rock for more efficient reclamation of value.
Exposed Drifts During Pit Operations

Exposed Drifts During Pit Operations

A feature seen in the pit is a Lamprophyre, or igneous dike comprised of ultramafic, silica-poor, magnesium-rich rock. Biotite phenocrysts can be seen in samples. This is regarded as an unusual feature.

Lamprophyre formation in Cresson Mine

Lamprophyre formation in Cresson Mine

 The big haul trucks carry 300 tons of rock from the mine to the crusher. The crusher is actually a series of crushers that reduce the ore to pieces roughly 3/4 inch in diameter.

Haul Truck Carrying Rock from Blasting Site to Crusher

Haul truck carrying rock from blasting site to crusher The crushed rock is blended with lime and then driven to the leach pile for extraction. Another load for the leach heap.